Human Phenotyping Core

Cores > Human Phenotyping Core

Dr. Corby Martin 
Dr. Leanne Redman
Dr. Amanda Staiano
Pediatric Exercise and Exergaming
Dr. Owen Carmichael
Imaging
Dr. Jeff Keller
Phenotyping of Older Populations
Kori Murray
Imaging
Abby Duhe
Maternal and Infant Phenotyping
Karissa Elsass
Remote Food Photography Method & SmartIntake

Comprehensive human phenotyping is critical for understanding risk factors of obesity, to understand mechanisms in health and disease, and to develop programs for obesity prevention and treatment at various stages of life. To accomplish these aims and as outlined in the figure, the Human Phenotyping Core provides state-of-the-art phenotyping services at different stages of life, from pregnancy and infancy through childhood, adulthood, and older age. The services of the Human Phenotyping Core directly support the overall focus of the Pennington/Louisiana NORC and provide members with services that: 1) support the full spectrum of obesity research, 2) provide specialized services for unique populations, such as pregnant women, infants, and children, and 3) allow for clinical and translational studies. Through the provision of these services and expertise, the Human Phenotyping Core has made a significant impact on the research of NORC members thus far and has provided critical resources to move the fields of nutrition and obesity research forward.

The Human Phenotyping Core is divided into two sub-cores, Energy Balance and Behavioral, and these sub-cores provide a comprehensive suite of services and expertise that supports innovative nutrition and obesity research and fosters translational projects.  True to the theme of the Pennington/Louisiana NORC, the Human Phenotyping Core enhances research on nutrition, obesity, and metabolic health through the lifespan by providing state-of-the-art services to support nutrition, obesity, and metabolic research broadly; and continuing to develop innovative research techniques to conduct clinical and translational research across the lifespan.

The services provided by the Human Phenotyping Core are summarized in the figure.  The Core has greatly expanded its ability to phenotype mothers, infants, and children as part of the Maternal and Infant Phenotyping Laboratory (MIL), while also retaining and enhancing its ability to phenotype individuals through the remainder of the lifespan, including adolescents, adults, and the elderly.  The Core has existing procedures to measure energy expenditure, body composition, food intake, and to deliver behavior modification programs in the clinic or remotely.  The Core also has created a human tissue bio-repository, including metabolic tissues (muscle, adipose) and biospecimens that are needed for translational studies of nutrition, obesity, and metabolic health relative to pregnancy (placenta, cord blood), infancy (breast milk), and childhood. Further, the Core continues to expand its imaging capabilities, including enhanced body composition and metabolism imaging. The Core also has the ability to conduct functional Magnetic Resonance Imaging (fMRI) studies, including studies that rely on visual stimuli as well as taste stimuli that are delivered via a gustometer. 

In summary, the Human Phenotyping Core provides users with an extensive array of expertise and cutting edge phenotyping capabilities, which allows users to phenotype individuals throughout the lifespan.



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